Reactive arthritis usually develops two to four weeks after infection and typically follows a limited course, with most people recovering from its symptoms in three to 12 months.
A tendency does exist for more severe and long-term disease in patients who test positive for HLA-B27, as well as in those who have a family history of spondyloarthritis.
In about 15 to 20 percent of people with ReA, the condition recurs, sometimes brought on by reinfection. There is also a possibility of developing a chronic form of arthritis. Though the chronic arthritis brought on by ReA is usually mild, a minority of people develop a more severe form of arthritis, or spondyloarthritis.