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Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis

For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum aminopeptidase 1 (ERAP1),…

Genetic Dissection of Acute Anterior Uveitis Reveals Similarities and Differences in Associations Observed With Ankylosing Spondylitis

To use high-density genotyping to investigate the genetic associations of acute anterior uveitis (AAU) in patients with and those without ankylosing spondylitis (AS).

Genetics of spondyloarthritis—beyond the MHC

Ankylosing spondylitis (AS), psoriasis and inflammatory bowel disease (IBD) often coexist in the same patient and in their families. In AS, genes within the MHC region, in particular HLA‑B27, account for nearly 25% of disease hereditability, with additional small contributions…

Help researchers understand the relationship between ankylosing spondylitis and gut microbes.

Note from SAA: We are delighted to inform you of this study led by Dr. James Rosenbaum, current member of SAA’s Medical and Scientific Advisory Board. Help researchers understand the relationship between ankylosing spondylitis and gut microbes. Recent scientific studies…

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